منابع مشابه
Viral Dynamics of Acute HIV-1 Infection
Viral dynamics were intensively investigated in eight patients with acute HIV infection to define the earliest rates of change in plasma HIV RNA before and after the start of antiretroviral therapy. We report the first estimates of the basic reproductive number (R(0)), the number of cells infected by the progeny of an infected cell during its lifetime when target cells are not depleted. The mea...
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Viral kinetics have been extensively studied in the past through the use of spatially well-mixed ordinary differential equations describing the time evolution of the diseased state. However, emerging spatial structures such as localized populations of dead cells might adversely affect the spread of infection, similar to the manner in which a counter-fire can stop a forest fire from spreading. I...
متن کاملViral Dynamics in HIV-1 Infection
levels fall to lower steady-state values that vary in differA great deal of progress has been made in understandent individuals and that are predictive of the rate of ing the molecular biology of HIV-1 replication (see redisease progression (Mellors et al., 1996). In untreated views by Cullen [1998], Chan and Kim [1998], and Littasymptomatic patients, the plasma HIV-1 RNA levels man [1998] in t...
متن کاملMembrane dynamics associated with viral infection
Viral replication and spreading are fundamental events in the viral life cycle, accounting for the assembly and egression of nascent virions, events that are directly associated with viral pathogenesis in target hosts. These processes occur in cellular compartments that are modified by specialized viral proteins, causing a rearrangement of different cell membranes in infected cells and affectin...
متن کاملViral dynamics in hepatitis B virus infection.
Treatment of chronic hepatitis B virus (HBV) infections with the reverse transcriptase inhibitor lamivudine leads to a rapid decline in plasma viremia and provides estimates for crucial kinetic constants of HBV replication. We find that in persistently infected patients, HBV particles are cleared from the plasma with a half-life of approximately 1.0 day, which implies a 50% daily turnover of th...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society B: Biological Sciences
سال: 2006
ISSN: 0962-8452,1471-2954
DOI: 10.1098/rspb.2006.3563